Search results for "Age at menopause"

showing 3 items of 3 documents

Age at menopause predicts age at onset of Parkinson's disease.

2006

We investigated the association between age at onset of Parkinson's disease (PD) and fertile life characteristics in 145 women. Linear regression analyses showed a significant correlation between age at PD onset and age at menopause (P = 0.003), between age at PD onset and fertile life duration (P = 0.008), and a nonsignificant correlation between PD onset and cumulative duration of pregnancies (P = 0.23). These results support the possible role of estrogens in PD.

AdultAgingmedicine.medical_specialtyParkinson's diseasePhysiologyDiseaseRisk AssessmentCentral nervous system diseaseDegenerative diseasefertile lifePregnancyRisk FactorsInternal medicineage at menopausemedicineHumansAge of OnsetRisk factorAgedAged 80 and overPregnancybusiness.industryParkinson DiseaseMiddle Agedmedicine.diseaseMenopauseEndocrinologyNeurologyParkinson’s diseaseLinear ModelsSettore MED/26 - NeurologiaFemalewomenNeurology (clinical)MenopauseAge of onsetbusiness
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Implications for Estrogens in Parkinson’s Disease

2006

Evidence from experimental and epidemiological studies suggests a role of sex hormones in the pathogenic process leading to neurodegenerative diseases, (i.e., Alzheimer's and Parkinson's disease). The effects of sexual steroid hormones are complex and vary with the events of women's fertile life. Estrogens are supposed to influence dopamine synthesis, metabolism, and transport; however, there is no consensus regarding the direction, locus, and mechanism of the effect of estrogens on the dopaminergic system. A neuroprotective effect of estrogens has been demonstrated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-animal models of Parkinson's disease (PD). Epidemiological studies indi…

Settore MED/26 - NeurologiaAge at menopause Parkinson's disease
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Menopause: The Concepts and the Biological Background

2017

The exhaustion of the follicular endowment in the ovary defines the biological basis of menopause. The clinical implications are the loss of menses and fertility. Menopause is preceded by a series of clinical phases, reflected in the Staging of Reproductive Aging Workshop (STRAW). STRAW includes the different reproductive stages, with the clinically impacting menopausal transition and the end of the reproductive life, represented by the late post-menopausal period. Epidemiological studies show that the age at menopause, globally considered at around 50 years, undergoes significant differences across the world regions. High socio-economic conditions may prolong the age at menopause, but othe…

medicine.medical_specialtybusiness.industrymedia_common.quotation_subjectAge at menopauseReproductive lifeFertilityOvarymedicine.diseaseMenopausemedicine.anatomical_structureEpidemiologyFollicular phasemedicinebusinessDemographymedia_common
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